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A05 - Molecular roles of the RNA-binding protein CLUH in the regulation of mitochondrial function

Elena Rugarli
CECAD Research Center/Institute for Genetics
University of Cologne

E-mail: elena.rugarli(at)uni-koeln.de
Phone: +49 - 221 / 478 84244
For more information and contact please visit the RUGARLI LAB.

Abstract
The number and composition of mitochondria vary between different tissues and in response to physiological stimuli. We have discovered that the evolutionary conserved protein CLUH is an RNA-binding protein specific for subset of nuclear-encoded mitochondrial proteins. Preliminary data indicate that CLUH is a master regulator of mitochondrial function in response to changing metabolic conditions and identified molecular interactors of CLUH, pointing to a link with the cytoskeleton and the mTOR signalling pathway. Here, we propose to unravel the molecular mechanism by which CLUH regulates target mRNAs and to examine how CLUH function is integrated with signalling pathways important for mitochondrial distribution and turnover and nutrient sensing.

Latest publications
Schatton, D., Pla-Martin, D., Marx, M.C., Hansen, H., Mourier, A., Nemazanyy, I., Pessia, A., Zentis, P., Corona, T., Kondylis, V., Barth, E., Schauss, A.C., Velagapudi, V., and Rugarli, E.I. (2017). CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J. Cell Biol. 216, 675-693. doi: 10.1083/jcb.201607019.

Wang, S., Jacquemyn, J., Murru, S., Martinelli, P., Barth, E., Langer, T., Niessen, C.M., and Rugarli, E.I. (2016). The mitochondrial m-AAA protease prevents demyelination and hair greying. PLoS Genet 12, e1006463.