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Z04 - Bioenergetics

Aleksandra Trifunovic
CECAD Forschungszentrum/Institut für Mitochondriale Erkrankungen und Alterung
Universitätsklinikum Köln
E-mail: aleksandra.trifunovic(at)uk-koeln.de
Phone: +49 - 221 / 478 84291
For more information and contact please visit the TRIFUNOVIC LAB.

Hamid Kashkar
CECAD Research Center/Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), University Hospital Cologne

E-mail: H.Kashkar(at)uni-koeln.de
Phone: +49 - 221 / 478 84091
For more information and contact please visit the KASHKAR LAB.

Abstract
Mitochondrial bioenergetics is of central importance in diverse cellular actions involved in cellular homeostasis and stress responses. However, the complexity and dynamics of mitochondrial energy metabolism represent a great challenge for the integrative understanding of how mitochondria interfere with cellular functions. Therefore, the Z04 project intends to build up a much-needed Bioenergetic facility that should fulfill the need for in-depth analysis of metabolic processes in cells.

Latest joint publication
Coutelle, O., Hornig-Do, H.T., Witt, A., Andree, M., Schiffmann, L.M., Liwschitz, M., Seeger, J.M., Piekarek, M., Brinkmann, K., Hallek, M., Krönke, M., Trifunovic, A., Eming, S.A., Wiesner, R.J., Hacker, U.T., and Kashkar, H. (2014). Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing. EMBO Mol. Med. 6, 624-639.