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A04 - Autophagy regulation by mitochondria

Martin Graef
Max Planck Institute for Biology of Ageing
Cologne

Phone: +49 221 / 37970 470         
E-mail: Martin.Graef@uni-koeln.de
For more information and contact please visit the GRAEF LAB.

Abstract

Mitochondria emerge as critical regulators of autophagy, a central homeostasis process and stress response, and induce or repress autophagy in a mitochondrial function and metabolism dependent manner. Our project analyses the role of mitochondria for autophagy regulation in a broad and unbiased approach by determining a mitochondria-centric genetic and metabolic interaction map of autophagy regulation. Additionally, we will dissect how mitochondria participate directly in the plastic and dynamic formation of autophagosomes.

Project-related publications

Schütter, M. and Graef, M. (2020). Localized de novo phospholipid synthesis drives autophagosome biogenesis. Autophagy 1-2. doi: 10.1080/15548627.2020.1725379. [Epub ahead of print]

Schütter, M., Giavalisco, P., Brodesser, S., and Graef, M. (2020). Local fatty acid channeling into phospholipid synthesis drives phagophore expansion during autophagy. Cell 180, 135-149.e14.  [Epub ahead of print]

Gross, A. and Graef, M. (2019). Mechanisms of autophagy in metabolic stress response. J. Mol. Biol., pii: S0022-2836(19)30559-5. DOI: 10.1016/j.jmb.2019.09.005. [Epub ahead of print].

Cui, R., Medeiros, T.C., Willemsen, D., Iasi, L.N.M., Collier, G.E., Graef, M., Reichard, M., and Valenzano, D.R. (2019). Relaxed selection limits lifespan by increasing mutation load. Cell 178, 385-399.

Medeiros, T.C., Thomas, R.L., Ghillebert, R., and Graef, M. (2018). Autophagy balances mtDNA synthesis and degradation by DNA polymerase POLG during starvation. J. Cell Biol. 217, 1601-1611.

Medeiros, T.C., and Graef, M. (2018). Autophagy determines mtDNA copy number dynamics during starvation. Autophagy 15, 178-179.

Graef, M. (2018). Lipid droplet-mediated lipid and protein homeostasis in budding yeast. FEBS letters 592, 1291-1303.

Velázquez, A.P., Tatsuta, T., Ghillebert, R., Drescher, I., and Graef, M. (2016). Lipid droplet-mediated ER homeostasis regulates autophagy and cell survival during starvation. J. Cell Biol. 212, 621-631.

Velazquez, A.P., and Graef, M. (2016). Autophagy regulation depends on ER homeostasis controlled by lipid droplets. Autophagy 12, 1409-1410.