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A04 - Autophagy regulation by mitochondria

Martin Graef
Max Planck Institute for Biology of Ageing

Phone: +49 221 / 37970 470         
E-mail: Martin.Graef@uni-koeln.de
For more information and contact please visit the GRAEF LAB.


Mitochondria emerge as critical regulators of autophagy, a central homeostasis process and stress response, and induce or repress autophagy in a mitochondrial function and metabolism dependent manner. Our project analyses the role of mitochondria for autophagy regulation in a broad and unbiased approach by determining a mitochondria-centric genetic and metabolic interaction map of autophagy regulation. Additionally, we will dissect how mitochondria participate directly in the plastic and dynamic formation of autophagosomes.

Latest publications
Medeiros, T.C., Thomas, R.L., Ghillebert, R., and Graef, M. (2018). Autophagy balances mtDNA synthesis and degradation by DNA polymerase POLG during starvation. J. Cell Biol. Mar 2018, jcb.201801168; DOI: 10.1083/jcb.201801168

Medeiros, T.C., and Graef, M. (2018). Autophagy determines mtDNA copy number dynamics during starvation. Autophagy. Oct 10:1-2. DOI: 10.1080/15548627.2018.1532263. [Epub ahead of print]

Velázquez, A.P., Tatsuta, T., Ghillebert, R., Drescher, I., and Graef, M. (2016). Lipid droplet-mediated ER homeostasis regulates autophagy and cell survival during starvation. J. Cell Biol. 212, 621-631.