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A06 - The role of mitochondrial dynamics in mtDNA maintenance

Nils-Göran Larsson
since 2019: Karolinska Institutet, Stockholm, Sweden

Max Planck Institute for Biology of Ageing, Cologne
LARSSON group at the MPI AGE

Fundamental principles for the organisation, distribution and maintenance of mtDNA in mammalian cells are poorly understood, despite the huge impact of altered mtDNA expression on mitochondrial and age-associated diseases. We will investigate how impaired mitochondrial outer membrane fusion affects nucleoid distribution and mtDNA mutation complementation. Furthermore, we will define nucleoid protein components in mouse tissues in vivo in conditions with altered mtDNA expression.

Latest publication
Kukat, C., Davies, K.M., Wurm, C.A., Spåhr, H., Bonekamp, N.A., Kühl, I., Joos, F., Polosa, P.L., Park, C.B., Posse, V., Falkenberg, M., Jakobs, S., Kühlbrandt, W., and Larsson, N.G. (2015). Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid. Proc. Natl. Acad. Sci. U. S. A. 112, 11288-11293.