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A07 - Role of mitochondrial fusion dynamics in synapse and circuit remodelling of the adult hippocampus

Matteo Bergami
CECAD Research Center
University Hospital Cologne

E-mail: matteo.bergamiSpamProtectionuk-koeln.de
Phone: +49 - 221 / 478 84250
For more information and contact please visit the BERGAMI LAB.

Abstract
Accumulating evidence suggest that mitochondrial energy failure at synaptic terminals may be central to neuronal degeneration. However, whether mitochondria directly contribute to synaptic homeostasis or may even possibly favour neuronal/synapse regeneration in the adult brain has been elusive. In this project, we specifically focus on key regulators of mitochondrial fusion dynamics in newly-generated neurons in vivo to pursue the central question whether mitochondria contribute to aspects of cellular plasticity underlying the remarkable synaptic and connectivity remodelling of adult hippocampal circuits.

Latest publications
Sprenger, H.G., Wani, G., Hesseling, A., König, T., Patron, M., MacVicar, T., Ahola, S., Wai, T., Barth, E., Rugarli, E.I., Bergami, M., Langer, T. (2019). Loss of the mitochondrial i‐AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med. 11 pii: e9288.

Göbel, J. Motori, E., and Bergami, M. (2018). Spatiotemporal control of mitochondrial network dynamics in astroglial cells. Biochem. Biophys. Res. Commun. 500, 17-25.

Jahn, H.M., Bergami, M. (2018). Critical periods regulating the circuit integration of adult-born hippocampal neurons. Cell Tissue Res. 371, 23-32.

Bergami, M., Masserdotti, G., Temprana, S., Motori, E., Eriksson, T.E., Göbel, J., Yang, S.M., Conzelmann, K.K., Schinder, A.F., Götz, M. and Berninger, B. (2015). A critical period for experience-dependent remodelling of adult-born neuron connectivity. Neuron 85, 710-717.