A04 | Regulation and function of POLG-mediated mtDNA degradation
Running time within the CRC 1218: 07/2016 - 06/2024.
Autophagy is a highly conserved process required for cellular homeostasis during basal and stress conditions. Defects in autophagy result in the degradation of mitochondrial genomes (mtDNA) via a novel mechanism. The mitochondrial DNA polymerase gamma catalyzes not only the synthesis but also the degradation of mtDNA via its inherent 3’-5’ exonuclease activity. Within this project, we are examining the cellular mechanisms regulating the balance of the synthetic and degradative activities of POLG. In addition, we are characterizing the physiological consequences of POLG-mediated mtDNA degradation.
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