Our Research Profile

Mitochondria are essential cell organelles that are best known for their function in cellular energy homeostasis. However, research in the last two decades has unravelled an unexpected complexity of mitochondria and multiple ways how mitochondria interact with their cellular environment. Mitochondria are now recognised as dynamic and plastic organelles that are integrated into a complex network of cellular signalling cascades. They both react to alterations in cellular physiology and are capable, in turn, to effect cell fate and function. These diverse and bi-directional interactions of mitochondria with the cell underline the complex role of mitochondria in health and disease.

The CRC 1218 will tackle the challenge of mitochondrial complexity using novel interdisciplinary and collaborative approaches.
Our research is divided into two complementary research areas:

Research Area A – Mitochondrial Dynamics and Quality control
Research Area B – Mitochondria in Stress Response and Disease

Research area A: Mitochondrial Dynamics and Quality Control

Projects in this area aim to clarify the link between mitochondrial structure and function, particularly under changing conditions and disease. Many highlight the bidirectional relationship between mitochondrial plasticity and metabolism, uncovering new aspects that shape future research. Collectively, these studies span from molecular mechanisms to organismal impact.

Research area B: Mitochondria in Stress Response and Disease

This research explores the cell-type specificity of mitochondrial diseases, examining how mitochondrial metabolism and morphology influence signaling, survival, and function. We study mitochondria-derived signals, reprogramming, and metabolism across various pathological contexts, as well as their interactions with pathogens and other organelles.