INF | Research Data management in interdisciplinary mitochondrial research
Hendrik Nolte
Max Planck Institute for Biology of Ageing,
Cologne
E-mail: h.nolte@age.mpg.de
Phone: +49 - 221 / 37 970 534
For more information and contact please visit the Langer Department at MPI Age.
Florian Willems
C³RDM, Regional Computing Centre (RRZK),
University of Cologne
E-mail: Willems
uni-koeln.de
Phone: +49 - 221 / 470 89609
For more information and contact please visit the C³RDM-Team
Oya Beyan
Institute for Biomedical Informatics,
University of Cologne
E-mail: Oya.Beyanuni-koeln.de
Phone: +49 - 221 / 478 82912
For more information and contact please visit the Institute of Biomedical Informatics
Running time within the CRC 1218: 06/2024 - 06/2028.
Abstract
Within the INF project, we aim to implement the infrastructural requirements to provide researchers with a set of standardized ontology, metadata templates, and teaching opportunities on FAIR data management. Moreover, we will closely cooperate with the IT department and core facilities to implement Data Integration Platforms (DIP) following the Investigation-Study-Assay concept requiring the storage of accompanying metadata to the raw data. The project aims to implement a user-friendly web application for exploring and analyzing proteomics data across funding periods. We will share the research outputs of the CRC1218 by uploading metadata onto a public metadata server, enabling the research community to explore the entirety of CRC1218 and submit data requests.
Project-related publications
Kaul H, Isermann L, Senft K, Popovic M, Georgomanolis T, Baumann L, Sivanesan P, Pouikli A, Nolte H, Lucic B, Hildebrandt X, Seidel K, Gnad T, Gaedke F, Göbel U, Peters F, Cherevatenko M, Park JH, Schauss A, Peltzer N, Brüning JC, Kornfeld JW, Pfeifer A, Langer T, Lusic M, Wickström SA, Frezza C, Trifunovic A. 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction. Nat Metab. 2025 Aug 1. doi: 10.1038/s42255-025-01332-8. Epub ahead of print. PMID: 40750944.
Altin S., Simóes T., Behrendt C., Anton V., Domke D., Völtzke K.M., Kumar R., Nolte H., Hermanns T., Brocke-Ahmadinejad N., Bendrin K., Zimmermann M., Büttner R., Ventura N., Krüger M., Dohmen R.J., Hofmann K., Hoppe T., Reichert A.S., Escobar-Henriques M. (2025). Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity. Mol Cell 85, 3677-3693.
Popovic M, Isermann L, Geißen S, Senft K, Georgomanolis T, Baldus S, Frezza C, Trifunovic A. Tissue-specific adaptations to cytochrome c oxidase deficiency shape physiological outcomes. Biochim Biophys Acta Mol Basis Dis. 2024 Nov 27:167567. doi: 10.1016/j.bbadis.2024.167567. Epub ahead of print. PMID: 39613003.Gehrmann J, Herczog E, Decker S, Beyan O (2023). What prevents us from reusing medical real-world data in research. Scientific Data 10:459. DOI: 10.1038/s41597-023-02361-2.
McQuilton P, Batista D, Beyan O, Granell R, Coles S, Izzo M, Lister AL, Pergl R, Rocca-Serra P, Schaap B, Shanahan H, Thurston M, Sansone SA (2020). Helping the Consumers and Producers of Standards, Repositories and Policies to Enable FAIR Data. Data Intelligence 2:151-157. DOI: 10.1162/dint_a_00037.
