A01 | LANGER
Proteolytic control of mitochondrial dynamics and metabolism by OMA1
Research area A: Mitochondrial structure, dynamics and function
The main goals of projects in this area are to elucidate the intricate communication between mitochondrial structure and the functional output of the organelles and how this is affected by changing cellular conditions and pathology. Intriguingly, many projects emphasised the intimate bidirectional connection between mitochondrial plasticity and metabolic programmes, and unravelled novel aspects that form the basis for the new research programme of this area.
In the second funding period, we have included novel projects that explore at the molecular resolution the role of specific proteins and protein complexes for the structural plasticity of mitochondria. Together, projects of this area will enable us to tackle our scientific questions from the molecular to the organismal level.
A03 | ESCOBAR-HENRIQUES
Cellular quality control by mitofusins and ubiquitin
A05 | RUGARLI
The role of CLUH in the translation of mRNAs encoding mitochondrial proteins
A07 | BERGAMI
Role of mitochondrial dynamics in neuronal synapse and circuit remodelling
A08 | BRÜNING
Bi-directional regulation of liver/brain interaction via hepatic mitochondrial fission
A12 | GARCIA SAEZ
Dynamic architecture of DRP1 macromolecular assemblies in mitochondrial fission
A13 | PIANO
Elucidate the regulatory cascade controlling mitochondrial fission in mitosis
A11 | MOTORI
Critical periods of mitochondrial structural and metabolic plasticity in Purkinje neurons