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B05 - Role of mitochondria in the regulation of intestinal epithelial cell death and inflammation

Manolis Pasparakis
CECAD Research Center/Institute for Genetics
University of Cologne

E-mail: pasparakis(at)uni-koeln.de
Phone: +49 - 221 / 478 84351
For more information and contact please visit the PASPARAKIS LAB.

Abstract
The project aims to study the role of mitochondria in the regulation of intestinal homeostasis and inflammation using genetic mouse models. Specifically, the possible in vivo role of mitochondrial fission in facilitating epithelial cell death (apoptotic, necroptotic) in response to immunological, microbial or chemical challenges will be addressed. In addition, we will address in vivo how mitochondrial oxidative phosphorylation defects affect epithelial cell function and intestinal homeostasis.

Latest publication
Kondylis, V., Polykratis, A., Ehlken, H., Ochoa-Callejero, L., Straub, B.K., Krishna-Subramanian, S., Van, T.M., Curth, H.M., Heise, N., Weih, F., Klein, U., Schirmacher, P., Kelliher, M., and Pasparakis, M. (2015). NEMO prevents steatohepatitis and hepatocellular carcinoma by inhibiting RIPK1 kinase activity mediated hepatocyte apoptosis. Cancer Cell 28, 582-598.