A11 - Critical periods of mitochondrial structural and metabolic plasticity in Purkinje neurons
Elisa Motori
Institute for Biochemistry | University of Cologne
E-mail: elisa.motori@uni-koeln.de
Phone: +49 (0) 221 470 76 056
Abstract
Mitochondria are highly dynamic organelles vital for the functioning and survival of neurons. Regulated
transport of mitochondria is a key process which has been suggested to sustain mitochondrial turnover
at synapses as well as axonal integrity. However, how local and long-range transport of mitochondria
is differentially regulated within specific sub-compartments - such as functionally distinct regions of
dendritic arbors - to match precise switches in synaptic development and consolidation in vivo is poorly
understood. By combining imaging and genetic approaches, in this project we will focus on the almost
unique architecture of Purkinje neurons to dissect the mutual regulation of mitochondrial motility and
compartment-specific synaptic functions.
Project-related publications
Wani, G.A., Sprenger, H.-G., Ndoci, K., Chandragiri, S., Acton, R.J., Schatton, D., Kochan, S.M.V., Sakthivelu, V., Jevtic, M., Seeger, J.M., Müller, S., Giavalisco, P., Rugarli, E.I., Motori, E., Langer, T., Bergami, M. (2022). Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L. Cell Reports • DOI:https://doi.org/10.1016/j.celrep.2022.110370