B12 - Cardiolipin metabolism in immunity, inflammation and ageing
Mauro Corrado
CECAD Research Center
E-mail: mcorrado
uni-koeln.de
Phone: +49 - 221 / 478 84167
For more information and contact please visit the CORRADO LAB.
Abstract
Cardiolipin is the distinctive inner mitochondrial membrane phospholipid coupling structure with metabolism and signaling function. The importance of cardiolipin in mitochondrial function is evidenced by the X-linked inherited pathology Barth syndrome that results from cardiolipin remodeling deficiency. Yet we understand little about the role it plays in mitochondrial and cellular biology beyond regulating OXPHOS efficiency and in other mitochondrial pathologies. This project will complement metabolic analysis, in vivo immunologic phenotyping and biochemical insight to investigate cardiolipin plasticity in immunity, inflammation and ageing.
Publications
Guhathakurta S, Erdogdu NU, Hoffmann JJ, Grzadzielewska I, Schendzielorz A, Seyfferth J, Mårtensson CU, Corrado M, Karoutas A, Warscheid B, Pfanner N, Becker T, Akhtar A (2023). COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function.Nat Metab. DOI: 10.1038/s42255-023-00904-w.
Corrado, M., Edwards-Hicks, J., Villa, M., Flachsmann, L.J., Sanin, D.E., Jacobs, M., Baixauli, F., Stanczak, M., Anderson, E., Azuma, M., Quintana, A., Curtis, J.D., Clapes, T., Grzes, K.M., Kabat, A.M., Kyle, R., Patterson, A.E., Geltink, R.K., Amulic, B., Steward, C.G., Strathdee, D., Trompouki, E., O'Sullivan, D., Pearce, E.J., Pearce, E.L. (2020). Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity. Cell. Metab. 32(6):981-995.e7. DOI: 10.1016/j.cmet.2020.11.003.