B10 | Role of mitochondria in the regulation of myeloid cell function in skin homeostasis and repair
Sabine Eming
Department of Dermatology, Medical Faculty,
University of Cologne
Phone: +49 221 / 478 3196
E-mail: Sabine.Eming
uni-koeln.de
For more information and contact please visit the EMING LAB.
Running time within the CRC 1218: 07/2020 - 06/2024.
Abstract
Skin injury induces a dynamic cellular programme proceeding in sequential phases of antimicrobial defence, followed by tissue growth and differentiation. Cells of the myeloid cell lineage are an essential component of the body’s innate ability to sense tissue damage and to restore tissue function after injury. The aim of this project is to understand the role of mitochondria in myeloid cells in skin homeostasis and repair. Understanding these mechanisms may help developing new therapies to treat patients suffering from impaired healing conditions.
Project-related publications
Willenborg, S., Sanin, D.E., Jais, A., Ding, X., Ulas, T., Nüchel, J., Popović, M., MacVicar, T., Langer, T., Schultze, J.L., Gerbaulet, A., Roers, A., Pearce, E.J., Brüning, J.C., Trifunovic, A., Eming, S.A. (2021). Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metabolism (2021), https://doi.org/10.1016/j.cmet.2021.10.004
Schiffmann, L.M., Werthenbach, J.P., Heintges-Kleinhofer, F., Seeger, J.M., Fritsch, M., Günther, S.D., Willenborg, S., Brodesser, S., Lucas, C., Jüngst, C., Albert, M.C., Schorn, F., Witt, A., Moraes, C.T., Bruns, C., Pasparakis, M., Krönke, M., Eming, S.A., Coutelle, O., Kashkar, H. (2020). Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth. Nat. Commun. 11:3653
Kiesewetter, A., Cursiefen, C., Eming, S.A.*, and Hos, D.* (2019). Phase-specific functions of macrophages determine injury-mediated corneal hem- and lymphangiogenesis. Sci. Rep. 9, 308. (*corresponding authors)
Do, N.N.*, Willenborg, S.*, Eckes, B., Sengle, G., Zauke, F., and Eming, S.A. (2018). Myeloid cell-restricted STAT3 signaling controls a cell autonomous anti-fibrotic repair program. J. Immunol. 201, 663-674. (* shared first authorship)
Eming, S.A., Wynn, T.A., and Martin, P. (2017). Inflammation and metabolism in tissue repair and regeneration. Science 356, 1026-1030.
Knipper, J.A., Willenborg, S., Brinckmann, J., Bloch, W., Maaß, T., Wagener, R., Krieg, T., Sutherland, T., Migge, T., Richardson, R., Hammerschmidt, M., Allen, J.E., and Eming, S.A. (2015). IL-4Rα signaling in myeloid cells controls collagen fibril assembly in skin repair. Immunity 43, 803-816.
Ding, X., Lucas, T., Marcuzzi, G.P., Pfister, H., and Eming, S.A. (2015). Distinct functions of epidermis- and myeloid cell specific VEGF-A in human papillomavirus type 8-mediated tumorigenesis. Cancer Res. 75, 330-343.
Knuever, J., Willenborg, S., Ding, X., Akyüz, M.D., Partridge, L., Niessen, C.M., Brüning, J.C., and Eming, S.A. (2015). Myeloid cell-restricted Insulin/IGF-1 receptor deficiency protects against skin inflammation. J. Immunol. 195, 5296-5308.
Eming, S.A., Martin, P., and Tomic-Canic, M. (2014). Wound Repair and Regeneration: Mechanisms, signaling, and translation. Sci. Transl. Med. 6, 265sr6.
Willenborg, S., Lucas, T., van Loo, G., Knipper, J., Krieg, T., Haase, I., Brachvogel, B., Hammerschmidt, M., Nagy, A, Ferrara, N., Pasparakis, M., and Eming, S.A. (2012). CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood 120, 613-625.
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., and Eming, S.A. (2010). Differential roles of macrophages in diverse phases of skin repair. J. Immunol. 184, 3964-3977.