Publications 2026

Colina-Teneorio, L., Horten, P., Scifo, E., Horvath, S.E., Klar, R.F.U., Priesnitz, C., den Brave, F., van der Laan, M., Becker, T., Song, K. and Rampelt, H. (2026) Mitochondrial contact site and cristae organizing system promotes modular assembly of cytochrome c oxidase. Cell Rep. 45, 116727. doi.org/10.1016/j.celrep.2025.116727

Publications 2025

Zhao, X.T., Diep, D.T.V., Perciful, L., Fausten, R.M., Hugenroth, M., Höhne, P., Leite, B., Esch, B.M., Collado, J., Keller, J., Wilmes, S., Turhan, M.A., Wälte, M., Becker, T., Kümmel, D., Schuberth, C., Fernandez-Busnadiego, R., Fröhlich, F., Wedlich-Söldner, R. and Bohnert, M. (2025) The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility. Cell Rep. 44, 116475. doi.org/10.1016/j.celrep.2025.116475

den Brave, F., Mishra, S. and Becker, T. (2025) Mitochondrial heterogeneity: subpopulations with distinct metabolic activities. Sig Transduct Target Ther. 10, 36. doi.org/10.1038/s41392-025-02130-0

Jackson, J. and Becker, T. (2025) Unclogging of the TOM complex under import stress. Biol. Chem. 406(5-7):251-262. doi.org/10.1515/hsz-2025-0110

Pfanner, N., den Brave, F., Becker, T. Mitochondrial protein import stress. Nat Cell Biol (2025). DOI:10.1038/s41556-024-01590-w.

Kaul H, Isermann L, Senft K, Popovic M, Georgomanolis T, Baumann L, Sivanesan P, Pouikli A, Nolte H, Lucic B, Hildebrandt X, Seidel K, Gnad T, Gaedke F, Göbel U, Peters F, Cherevatenko M, Park JH, Schauss A, Peltzer N, Brüning JC, Kornfeld JW, Pfeifer A, Langer T, Lusic M, Wickström SA, Frezza C, Trifunovic A. 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction. Nat Metab. 2025 Aug 1. doi: 10.1038/s42255-025-01332-8. Epub ahead of print. PMID: 40750944.

Altin S., Simóes T., Behrendt C., Anton V., Domke D., Völtzke K.M., Kumar R., Nolte H., Hermanns T., Brocke-Ahmadinejad N., Bendrin K., Zimmermann M., Büttner R., Ventura N., Krüger M., Dohmen R.J., Hofmann K., Hoppe T., Reichert A.S., Escobar-Henriques M. (2025). Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity. Mol Cell 85, 3677-3693.

Joaquim M, Altin S, Bulimaga MB, Simões T, Nolte H, Bader V, Franchino CA, Plouzennec S, Szczepanowska K, Marchesan E, Hofmann K, Krüger M, Ziviani E, Trifunovic A, Chevrollier A, Winklhofer KF, Motori E, Odenthal M, Escobar-Henriques M. Mitofusin 2 displays fusion-independent roles in proteostasis surveillance. Nat Commun. 2025 Feb 10;16(1):1501. doi: 10.1038/s41467-025-56673-5. PMID: 39929801; PMCID: PMC11811173.

Li Q., Weiss K., Niwa F., Riemer J., Hoppe T. (2025). Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration. Nat Cell Biol. doi: 10.1038/s41556-025-01799-3. 

Charmpilas N., Li Q., Hoppe T. (2025). The mitochondrial unfolded protein response: acting near and far. Biol Chem. 406, 229-236.

Popovic M, Isermann L, Geißen S, Senft K, Georgomanolis T, Baldus S, Frezza C, Trifunovic A. (2025) Tissue-specific adaptations to cytochrome c oxidase deficiency shape physiological outcomes. Biochim Biophys Acta Mol Basis Dis. 2024 Nov 27:167567. doi: 10.1016/j.bbadis.2024.167567. Epub ahead of print. PMID: 39613003.

Steymans, I., and Becker, T. (2024) Monitoring α-helical membrane protein insertion into the outer membrane of yeast cells. Methods Enzym. 707, 39-62. doi.org/10.1016/bs.mie.2024.07.055

Zaninello M, Schlegel T, Nolte H, Pirzada M, Savino E, Barth E, Klein I, Wüstenberg H, Uddin T, Wolff L, Wirth B, Lehmann HC, Cioni JM, Langer T, Rugarli EI (2024). CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy. Sci Adv. 10(22):eadn2050. DOI: 10.1126/sciadv.adn2050. 

Henschke S, Nolte H, Magoley J, Kleele T, Brandt C, Hausen AC, Wunderlich CM, Bauder CA, Aschauer P, Manley S, Langer T, Wunderlich FT, Brüning JC. (2024). Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver. Science 384(6694):438-446. DOI: 10.1126/science.adk1005.

Froehlich T, Jenner A, Cavarischia-Rega C, Fagbadebo FO, Lurz Y, Frecot DI, Kaiser PD, Nueske S, Scholz AM, Schäffer E, Garcia-Saez AJ, Macek B, Rothbauer U (2024). Nanobodies as novel tools to monitor the mitochondrial fission factor Drp1. Life Sci Alliance 7(8):e202402608. DOI: 10.26508/lsa.202402608.

Filograna R, Gerlach J, Choi HN, Rigoni G, Barbaro M, Oscarson M, Lee S, Tiklova K, Ringnér M, Koolmeister C, Wibom R, Riggare S, Nennesmo I, Perlmann T, Wredenberg A, Wedell A, Motori E, Svenningsson P, Larsson NG (2024). PARKIN is not required to sustain OXPHOS function in adult mammalian tissues. NPJ Parkinsons Dis. 10(1):93. DOI: 10.1038/s41531-024-00707-0.

Müller L, Salman S, Hoppe T (2024). Chemical cross-linking to study protein self-assembly in cellulo. STAR Protoc, 2024 vol. 5(2) p. 103032. DOI: doi: 10.1016/j.xpro.2024.103032.

Borgert L, Becker T, den Brave F (2024). Conserved quality control mechanisms of mitochondrial protein import. J. Inherit. Metab. Dis. DOI:10.1002/jimd.12756.

Busto JV, Ganesan I, Mathar H, Steiert C, Schneider EF, Straub SP, Ellenrieder L, Song J, Stiller SB, Lübbert P, Chatterjee R, Elsaesser J, Melchionda L, Schug C, den Brave F, Schulte U, Klecker T, Kraft C, Fakler B, Becker T, Wiedemann N (2024). Role of the small protein Mco6 in the mitochondrial sorting and assembly machinery. Cell Rep. 43, 113805. DOI: 10.1016/j.celrep.2024.113805.

Horten P, Song K, Garlich J, Hardt R, Colina-Tenorio L, Horvath SE, Schulte U, Fakler F, van der Laan M, Becker T, Stuart RA, Pfanner N,  Rampelt H (2024). Identification of MIMAS, a multifunctional mega-assembly integrating metabolic and respiratory biogenesis factors of mitochondria. Cell Rep. 43, 113772. DOI: 10.1016/j.celrep.2024.113772.

Bhowmik R, den Brave F, Becker T (2024). Modular assembly of mitochondrial b-barrel proteins. Chapter in transmembrane-barrel proteins: methods and protocols: Methods Mol. Biol. 2778, 201-220. DOI: 10.1007/978-1-0716-3734-0_13.

den Brave F, Pfanner N, Becker T (2024). Mitochondrial entry gate as regulatory hub. Biochim. Biophys. Acta 1871, 119529. DOI: 10.1016/j.bbamcr.2023.119529.

den Brave, F., Schulte, U., Fakler, B., Pfanner, N. and Becker, T. (2024) Mitochondrial complexome and import network. Trends Cell Biol. 34(7):578-594.

Moschandrea C, Kondylis V, Evangelakos I, Herholz M, Schneide F, Schmidt C, Yang M, Ehret S, Heine H, Jaeckstein MJ, Szczepanowska K, Schwarzer R, Baumann L, Bock T, Nikitopoulou E, Brodesser S, Krüger M, Frezza C, Heeren J, Trifunovic A*, Pasparakis M* (2023). Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature. DOI: 10.1038/s41586-023-06857-0. *corresponding authors

Guhathakurta S, Erdogdu NU, Hoffmann JJ, Grzadzielewska I, Schendzielorz A, Seyfferth J, Mårtensson CU, Corrado M, Karoutas A, Warscheid B, Pfanner N, Becker T, Akhtar A (2023). COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function. Nat Metab. DOI: 10.1038/s42255-023-00904-w.

Schorn, F., Werthenbach, J. P., Hoffmann, M., Daoud, M., Stachelscheid, J., Schiffmann, L.M., Hildebrandt, X., Lyu, S.I., Peltzer, N., Quaas, A., Vucic, D., Silke, J., Pasparakis, M., Kashkar, H. (2023). cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. The EMBO Journal 2023 Oct 4:e113614. DOI: 10.15252/embj.2023113614

Anton, V., Buntenbroich, I., Simões, T., Joaquim, M., Müller, L., Büttner, R., Odenthal, M., Hoppe, T., Escobar-Henriques, M. (2023). E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response. Molecular Cell. DOI: doi.org/10.1016/j.molcel.2023.07.021. (Open access).

Czabotar, P.E., García-Sáez, A.J. (2023). Mechanisms of BCL-2 family proteins in mitochondrial apoptosis. Nat Rev Mol Cell Biol. 2023 Jul 12. doi: 10.1038/s41580-023-00629-4.

Buntenbroich, I., Anton, V., Perez-Hernandez, D., Simões, T., Gaedke, F., Schauss, A., Dittmar, G., Riemer, J., Escobar-Henriques, M. (2023).  Docking and stability defects in mitofusin highlight the proteasome as a potential therapeutic target. iScience. 2023 Jun 7;26(7):107014. doi: 10.1016/j.isci.2023.107014

Peker, E., Weiss, K., Song, J., Zarges, C., Gerlich, S., Boehm, V., Trifunovic, A., Langer, T., Gehring, N., Becker, T. and Riemer, J. (2023). A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis. J. Cell Biol. 222, e202210019.

Coyne, L.P., Wang, X., Song, J., de Jong, E., Schneider, K., Massa, P.T., Middleton, F.A., Becker, T. and Chen, X.J. (2023). Mitochondrial protein import clogging as a mechanism of disease. eLife 12, e84330.

Montoro-Gámez, C., Nolte, H., Molinié, T., Evangelista, G., Tröder, S., Barth, E., Popovic, M., Trifunovic, A., Zevnik, B., Langer, T., Rugarli E.I. SARM1 deletion delays cerebellar but not spinal cord degeneration in an enhanced mouse model of SPG7 deficiency. Brain. 2023 Apr 22:awad136. doi: 10.1093/brain/awad136. Online ahead of print. PMID: 37086482

Flores-Romero, H., Dadsena, S., García-Sáez, A.J. (2023). Mitochondrial pores at the crossroad between cell death and inflammatory signaling. Mol Cell. 2023 Mar 16;83(6):843-856. doi: 10.1016/j.molcel.2023.02.021.

Hevler, J. F., Albanese, P., Cabrera-Orefice, A., Potter, A., Jankevics, A., Misic, J., Scheltema, R.A., Brandt, U., Arnold, S.,  and Heck, A.J.R. (2023) MRPS36 provides a structural link in the eukaryotic 2-oxoglutarate dehydrogenase complex. Open Bio. 2023 Mar;13(3):220363. doi: 10.1098/rsob.220363. Epub 2023 Mar 1.

Li, Q. and Hoppe, T. (2023). Role of amino acid metabolism in mitochondrial homeostasis. Front Cell Dev Biol. 10.3389/fcell.2023.1127618

Schulte, U.; den Brave, F., Haupt, A., Gupta, A., Song, J., Müller, C.S., Engelke, J., Mishra, S., Mårtensson, C., Ellenrieder, L., Priesnitz, C., Straub, S.P., Doan, K.N., Kulawiak, B., Bildl, W., Rampelt, H., Wiedemann, N., Pfanner, N., Fakler, B. and Becker, T. Mitochondrial complexome reveals quality control pathways of protein import (2023). Nature. doi.org/10.1038/s41586-022-05641-w.

Takeda, H., Busto, J.V., Lindau, C., Tsutsumi, A., Tomii, K., Imai, K., Yamamori, Y., Hirokawa, T., Motono, C., Ganesan, I., Wenz, L.S., Becker, T., Kikkawa, M., Pfanner, N., Wiedemann, N. and Endo, T. (2023) A multipoint guidance mechanism for b-barrel folding on the SAM complex. Nat. Struct. Mol. Biol. doi.org/10.1038/s41594-022-00897-2.

Song, J., Steidle, L., Steymans, I., Singh, J., Sanner, A., Böttinger, L., Winter, D. and Becker, T. (2023). The mitochondrial Hsp70 controls the assembly of the F1FO-ATP synthase. Nat. Commun. 14, 39.

Hermeling, J. CW., Herholz, M., Baumann, L., Cores, E.C., Zečić, A., Hoppe, T., Riemer, J., Trifunovic, A. (2022). Mitochondria-originated redox signalling regulates KLF-1 to promote longevity in Caenorhabditis elegans. Redox Biology 2022,  https://doi.org/10.1016/j.redox.2022.102533

Jacobs, L.J., Hoehne, M.N., Riemer, J. (2022). Measuring Intracellular H2O2 in Intact Human Cells Using the Genetically Encoded Fluorescent Sensor HyPer7. Bio-protocol 12 (20).

Kožich, V, Schwahn, B.C., Sokolová, J., Křížková, M., Ditroi, T., Krijt, J., Khalil, Y., Křížek, T., Vaculíková-Fantlová, T., Stibůrková, B., Mills, P., Clayton, P., Barvíková, K., Blessing, H., Sykut-Cegielska, J., Dionisi-Vici, C., Gasperini, S., García-Cazorla, Á., Haack, T.B., Honzík, T., Ješina, P., Kuster, A., Laugwitz, L., Martinelli, D., Porta, F., Santer, R., Schwarz, G., Nagy, P. (2022). Human ultrarare genetic disorders of sulfur metabolism demonstrate redundancies in H₂S homeostasis. Redox Biol. 2022 Dec;58:102517. doi: 10.1016/j.redox.2022.102517. Epub 2022 Oct 18.PMID: 36306676. Free PMC article.

Rödl, S., den Brave, F., Räschle, M., Kizmaz, B., Lenhard, S., Groh, C., Becker, H., Zimmermann, J., Morgan, B., Richling, E., Becker, T. and Herrmann, J.M. (2022). The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import. Life Sci. Alliance 6, e202201526.

Bolgi, O., Silva-Garcia, M., Ross, B., Pilla, E., Kari, V., Killisch, M., Spitzner, M., Stark, N., Lenz, C., Weiss, K., Donzelli, L., Gorrell, M.D., Grade, M., Riemer, J., Urlaub, H., Dobbelstein, M., Huber, R., Geiss-Friedlander, R. (2022). Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair. EMBO Rep. e54136.

Ravanelli, S., Li, Q., Annibal, A., Trifunovic, A., Antebi, A., Hoppe, T. (2022). Reprograming of proteasomal degradation by branched chain amino acid metabolism.  Aging Cell 2022, https://doi.org/10.1111/acel.13725

Ahola, M., Rivera, M. P., Hermans, S., Chandragiri, S., Giavalisco, P., Nolte, H., Langer, T. (2022). OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy.  Cell Metab. 2022 Sep 8;S1550-4131(22)00360-6. doi: 10.1016/j.cmet.2022.08.017.

Jacobs, L.J., Riemer, J. (2022) Maintenance of small molecule redox homeostasis in mitochondria. FEBS Lett. doi: 10.1002/1873-3468.

Balaji, V., Müller, L., Lorenz, R., Kevei, E., Zhang, W.H., Santiago, U., Gebauer, J., Llamas, E., Vilchez, D., Camacho, C.J., Pokrzywa, W., Hoppe T. (2022). A Dimer-Monomer Switch Controls CHIP-Dependent Substrate Ubiquitylation and Processing. Mol Cell. 2022, doi: https://doi.org/10.1016/j.molcel.2022.08.003

Patron, M., Tarasenko, D., Nolte, H., Ghosh, M.,  Ohba, Y., Lasarzewski, Y., Ahmadi, Z.A., Cabrera-Orefice, A., Eyiama, A., Kellermann, T., Rugarli, E.I., Brandt, U., Meinecke, M., Langer, T. (2022). Regulation of mitochondrial proteostasis by the proton gradient. The EMBO Journal (2022)e110476. https://doi.org/10.15252/embj.2021110476

Salscheider, S.L., Gerlich, S., Cabrera-Orefice, A., Peker, E., Rothemann, R.A., Murschall, L.M., Finger, Y., Szczepanowska, K., Ahmadi, Z.A., Guerrero-Castillo, S., Erdogan, A., Becker, M., Ali, M., Habich, M., Petrungaro, C., Burdina, N., Schwarz, G., Klußmann, M., Neundorf, I., Stroud, D.A., Ryan, M.T., Trifunovic, A., Brandt, U., Riemer, J. (2022). AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5. The EMBO Journal (2022)e110784. https://doi.org/10.15252/embj.2022110784

Flores-Romero, H., García-Sáez, A.J. (2022). MERLIN: A BRET-Based Proximity Biosensor for Studying Mitochondria-ER Contact Sites. Methods Mol Biol. 2022;2525:197-205. doi: 10.1007/978-1-0716-2473-9_14.

Schatton, D., Di Pietro, G., Szczepanowska, K., Veronese, M., Marx, M.-C., Braunöhler, K., Esther, B., Müller, S., Giavalisco, P., Langer, T., Trifunovic, A., Rugarli, I.E. (2022). CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression. Elife. 2022 May 13;11:e74552. DOI: 10.7554/eLife.74552

Hoffmann, J.J. and Becker, T. (2022) Crosstalk between mitochondrial protein import and lipids. Int. J. Mol. Sci. 23, 5275.

Croon, M., Szczepanowska, K., Popovic, M., Lienkamp, C., Senft, K., Brandscheid, C.P., Bock, T., Gnatzy-Feik, L., Ashurov, A., Acton, R.J., Kaul, H., Pujol, C., Rosenkranz, S., Krüger, M., Trifunovic, A. (2022). FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction. Sci Adv. 2022 Apr 8;8(14):eabn7105

Priesnitz, C., Böttinger, L., Zufall, N., Gebert, M., Guiard, B., van der Laan, M. and Becker, T. (2022) Coupling to Pam16 differentially controls the dual role of Pam18 in protein import and respiratory chain formation. Cell Rep. 39, 1108619.

Song, J. and Becker T. (2022). Fidelity of organellar protein targeting. Curr. Opin. Cell Biol. 75:102071.

Rumyantseva, A., Popovic, M., Trifunovic, A. (2022). CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis. Brain (Oxford Academic) awab303, https://doi.org/10.1093/brain/awab303

Cosentino, K., Hertlein, V., Jenner, A., Dellmann, T., Gojkovic, M., Peña-Blanco, A., Dadsena, S., Wajngarten, N., Danial, J.S.H., Thevathasan, J.V., Mund, M., Ries, J., Garcia-Saez, A.J. (2022).
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation. Mol Cell. 2022 Mar 3;82(5):933-949.e9. doi: 10.1016/j.molcel.2022.01.008. Epub 2022 Feb 3.

Wani, G.A., Sprenger, H.-G., Ndoci, K., Chandragiri, S., Acton, R.J., Schatton, D., Kochan, S.M.V., Sakthivelu, V., Jevtic, M., Seeger, J.M., Müller, S., Giavalisco, P., Rugarli, E.I., Motori, E., Langer, T., Bergami, M. (2022). Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L. Cell Reports • DOI:https://doi.org/10.1016/j.celrep.2022.110370

Hoehne, M.N., Jacobs, L.J.H.C., Lapacz, K.J., Calabrese, G., Murschall, L.M., Marker, T., Kaul, H., Trifunovic, A., Morgan, B., Fricker, M., Belousov, V.V., Riemer J. (2022). Spatial and temporal control of mitochondrial H2O2 release in intact human cells. EMBO J, e109169

Gibhardt, C.S., Riemer, J., Bogeski, I. (2022). Calcium and redox signals at mitochondrial interfaces: A nanoview perspective. Cell Calcium 103:102550

Li, X., Straub, J., Medeiros, T.C., Den Brave, F., Peker, E., Atanassov, I., Stillger, K., Michaelis, J.B., Burbridge, E., Adrain, C., Münch, C., Riemer, J., Becker, T., Pernas, L.F. (2022). Mitochondria shed their outer membrane in response to infection-induced stress. Science  • Vol 375, Issue 6577 • DOI: 10.1126/science.abi4343

Flores-Romero, H., Hohorst, L., John, M., Albert, M-C., King, L. E, Beckmann, L., Szabo, T., Hertlein, V., Luo, X., Villunger, A., Frenzel, L. P., Kashkar, H., Garcia-Saez, A. J. (2021). BCL-2-family protein tBID can act as a BAX-like effector of apoptosis. The EMBO Journal (2021)e108690. https://doi.org/10.15252/embj.2021108690

Willenborg, S., Sanin, D.E., Jais, A., Ding, X., Ulas, T., Nüchel, J., Popović, M., MacVicar, T., Langer, T., Schultze, J.L., Gerbaulet, A., Roers, A., Pearce, E.J., Brüning, J.C., Trifunovic, A., Eming, S.A. (2021). Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing.  Cell Metabolism (2021), https://doi.org/10.1016/j.cmet.2021.10.004

Winter, D. and Becker, T. (2021). Surveying the mitochondrial proteome. Nature Cell Biology 23, 1216-1217.

den Brave, F., Gupta, A., Becker, T. (2021) Protein Quality Control at the Mitochondrial Surface. Front. Cell Dev. Biol. DOI: https://doi.org/10.3389/fcell.2021.795685

Kaczmarek, A.T., Bender, D., Gehling, T., Kohl, J.B., Daimagüler, H.S., Santamaria-Araujo, J.A., Liebau, M.C., Koy, A., Cirak, S., Schwarz, G.J. (2021). A defect in molybdenum cofactor binding causes an attenuated form of sulfiteoxidase deficiency. Inherit Metab Dis. 2022 Mar;45(2):169-182. Do i: 10.1002/jimd.12454. Epub 2021 Nov 24.PMID: 34741542

Guerrero-Castillo, S., van Strien J., Brandt, U. and Arnold, S. (2021) Ablation of mitochondrial DNA results in widespread remodeling of the mitochondrial complexome. EMBO Journal, 40, e108648.

Kaczmarek, A.T., Bahlmann, N., Thaqi, B., May, P., Schwarz, G. (2021). Machine learning-based identification and characterization of 15 novel pathogenic SUOX missense mutations. 2021 Sep-Oct;134(1-2):188-194. doi: 10.1016/j.ymgme.2021.07.011. Epub 2021 Aug 8.PMID: 34420858

Hevler J.F., Chiozzi, R.Z., Cabrera-Orefice, A., Brandt U., Arnold, S, and Albert J. R. Heck, A.J.R. (2021) Molecular characterization of a complex of apoptosis-inducing factor 1 with cytochrome c oxidase of the mitochondrial respiratory chain. Proc. Natl. Acad. Sci. USA, 118, e2106950118.

den Brave, F., Engelke, J. and Becker, T. (2021) Quality control of protein import into mitochondria. Biochem. J. 478, 3125-3143.

Bock, T., Türk, C., Aravamudhan, S., Keufgens, L., Bloch, W., Rozsivalova, D.H., Romanello, V., Nogara, L., Blaauw, B., Trifunovic, A., Braun, T., Krüger, M. (2021). PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B. Nat Commun. 2021 Aug 12;12(1):4900

Geueke A., Mantellato G., Kuester F., Schettina P., Nelles M., Seeger J.M., Kashkar H., Niemann C. (2021)
The anti-apoptotic Bcl-2 protein regulates hair follicle stem cell function
EMBO Rep (2021)e52301. https://doi.org/10.15252/embr.202052301

Murschall, L,M*., Peker, E*., MacVicar, T., Langer, T., Riemer, J. (2021). Protein Import Assay into Mitochondria Isolated from Human Cells. Bio-protocol 11 (12), e4057-e4057

Peker, E., Erdogan, A.J., Volkov, A.N., Riemer, J. (2021). Erv1 and Cytochrome c Mediate Rapid Electron Transfer via A Collision-Type Interaction. J Mol Biol. 433(15):167045

Schlagowski, A.M., Knöringer, K., Morlot, S., Sánchez Vicente, A., Flohr, T., Krämer, L., Boos, F., Khalid, N., Ahmed, S., Schramm, J., Murschall, L.M., Haberkant, P., Stein, F., Riemer, J., Westermann, B., Braun, R.J., Winklhofer, K.F., Charvin, G., Herrmann, J.M. (2021). Increased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol. EMBO J. e107913

Kaspar S., Oertlin C., Szczepanowska K., Kukat A., Senft K., Lucas C., Brodesser S., Hatzoglou M., Larsson O., Topisirovic I., Trifunovic A. (2021)
Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR
Science Advances  26 May 2021: Vol. 7, no. 22, eabf0971; DOI: 10.1126/sciadv.abf0971

Szczepanowska, K., Trifunovic, A. (2021). "Mitochondrial matrix proteases: quality control and beyond. " FEBS J. 2021 May 10

Müller, L., Kutzner, C.E., Balaji, V., Hoppe, T. (2021). In vitro analysis of E3 ubiquitin ligase function. J Vis Exp. 171, doi: 10.3791/62393.

He L., Sehrawat T.S., Verma V.K, Navarro-Corcuera A., Sidhu G., Mauer A., Luo X., Katsumi T., Chen J., Shah S., Arab J.P., Cao S., Kashkar H., Gores G.J., Malhi H., Shah V.H. (2021)
XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent in vitro and in vivo Phenotypes Owing to a Potential Zonal Inhibitory Role of SMAC
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