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A07 | Role of mitochondrial dynamics in neuronal synapse and circuit remodelling

Matteo Bergami
CECAD Research Center
University Hospital Cologne

E-mail: matteo.bergamiSpamProtectionuk-koeln.de
Phone: +49 - 221 / 478 84250
For more information and contact please visit the BERGAMI LAB.

Running time within the CRC 1218: 07/2016 - 06/2024.
 

Abstract

Dysfunctional mitochondrial dynamics play a central role in the development of several neurodegenerative disorders. While some of the basic processes controlling fission-fusion as well as movement of mitochondria have been revealed, our understanding of the mechanisms that ensure mitochondrial distribution across complex neuronal geometries and their role in neuronal plasticity are still rudimentary. In this project, we investigate how mitochondrial dynamics regulate the maintenance of specific neuronal circuits and how their becoming dysfunctional potentially contributes to maladaptive changes in neuronal connectivity which are linked to the onset of epileptic seizures.


Project-related publications

Gӧbel, J., Engelhardt, E., Pelzer, P., Sakthivelu, V., Jahn, H.M., Jevtic, M., Folz-Donahue, K., Kukat, C.,  Schauss, A., Frese, C. K., Giavalisco, P., Ghanem, A., Conzelmann, K.K., Motori, E., and Bergami, M. (2020). Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling. Cell Metab. https://doi.org/10.1016/j.cmet.2020.03.005 [in press, corrected proof]

Rangaraju, V.*, Lewis, T.*, Hirabayashi, Y.*, Bergami, M.*, Motori, E.*, Cartoni, R.*, Kwon, S.K., and Courchet, J. (2019). Pleiotropic Mitochondria: The influence of mitochondria on neuronal development and disease. J. Neurosci. 39, 8002-8208. *equal contribution

Ren, S.Q., Li, Z., Lin, S., Bergami, M., and Shi, S.H. (2019). Precise long-range microcircuit-to-microcircuit communication connects the frontal and sensory cortices in the mammalian brain. Neuron. 104, 385-401.e3.

Sprenger, H.G., Wani, G., Hesseling, A., König, T., Patron, M., MacVicar, T., Ahola, S., Wai, T., Barth, E., Rugarli, E.I., Bergami, M., Langer, T. (2019). Loss of the mitochondrial i‐AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol. Med. 11 pii: e9288.

Göbel, J., Pelzer, P., Engelhardt, E., Sakthivelu, V., Jahn, H.M., Milica, J., Folz-Donahue, K., Schauss, A., Ghanem, A., Conzelmann,, K.K., Frese, C., Motori, E., Bergami, M. (2019). Mitochondrial fusion in reactive astrocytes coordinates local metabolic domains to promote vascular repair. BioRxiv, doi: https://doi.org/10.1101/657999.

Göbel, J. Motori, E., and Bergami, M. (2018). Spatiotemporal control of mitochondrial network dynamics in astroglial cells. Biochem. Biophys. Res. Commun. 500, 17-25.

Jahn, H.M., Bergami, M. (2018). Critical periods regulating the circuit integration of adult-born hippocampal neurons. Cell Tissue Res. 371, 23-32.

Bergami, M., Masserdotti, G., Temprana, S., Motori, E., Eriksson, T.E., Göbel, J., Yang, S.M., Conzelmann, K.K., Schinder, A.F., Götz, M. and Berninger, B. (2015). A critical period for experience-dependent remodelling of adult-born neuron connectivity. Neuron 85, 710-717.