A07 | Role of mitochondrial dynamics in neuronal synapse and circuit remodelling
Matteo Bergami
CECAD Research Center
University Hospital Cologne
E-mail: matteo.bergami
uk-koeln.de
Phone: +49 - 221 / 478 84250
For more information and contact please visit the BERGAMI LAB.
Running time within the CRC 1218: 07/2016 - 06/2028.
Abstract
Maintenance of a functional mitochondrial network in neurons depends upon highly regulated mitochondrial dynamics. While mutations of genes implicated in mitochondrial dynamics cause neurological and degenerative disorders, it remains unclear how these processes regulate physiological changes at synapses. Here, we will tackle this question by combining super-resolution live imaging, P-proteomics screenings, and mouse genetics to unveil how changes in mitochondrial dynamics and function at dendritic spines are coupled with the induction of synaptic plasticity.
Project-related publications
Kochan SMV, Cepero Malo M, Jevtic M, Jahn HM, Wani G, Gaedke F, Schäffner I, Chichung-Lie D, Schauss A, Bergami M (2023). Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons. BioRxiv. DOI: https://doi.org/10.1101/2023.05.11.540324
Wani, G.A., Sprenger, H.G., Ndoci, K., Chandragiri, S., Acton, R.J., Schatton, D., Kochan, S.M.V., Sakthivelu, V., Jevtic, M., Seeger, J.M., Müller, S., Giavalisco, P., Rugarli, E.I., Motori, E., Langer, T., Bergami, M. (2022). Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L. Cell Reports • DOI:https://doi.org/10.1016/j.celrep.2022.110370
Bergami M., Motori E. (2020). Reweaving the Fabric of Mitochondrial Contact Sites in Astrocytes. DOI: 10.3389/fcell.2020.592651.
Gӧbel, J., Engelhardt, E., Pelzer, P., Sakthivelu, V., Jahn, H.M., Jevtic, M., Folz-Donahue, K., Kukat, C., Schauss, A., Frese, C. K., Giavalisco, P., Ghanem, A., Conzelmann, K.K., Motori, E., and Bergami, M. (2020). Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling. Cell Metab. Cell Metab 31:791-808 e798. DOI: 10.1016/j.cmet.2020.03.005.
Ricke, K.M., Paß, T., Kimoloi, S., Fährmann, K., Jüngst, C., Schauss, A., Baris, O.R., Aradjanski, M., Trifunovic, A., Eriksson Faelker, T.M., Bergami, M., Wiesner, R.J. (2020). Mitochondrial Dysfunction Combined with High Calcium Load Leads to Impaired Antioxidant Defense Underlying the Selective Loss of Nigral Dopaminergic Neurons. J Neurosci. 2020 Feb 26;40(9):1975-1986
Rangaraju, V.*, Lewis, T.*, Hirabayashi, Y.*, Bergami, M.*, Motori, E.*, Cartoni, R.*, Kwon, S.K., and Courchet, J. (2019). Pleiotropic Mitochondria: The influence of mitochondria on neuronal development and disease. J. Neurosci. 39, 8002-8208. *equal contribution
Ren, S.Q., Li, Z., Lin, S., Bergami, M., and Shi, S.H. (2019). Precise long-range microcircuit-to-microcircuit communication connects the frontal and sensory cortices in the mammalian brain. Neuron. 104, 385-401.e3.
Sprenger, H.G., Wani, G., Hesseling, A., König, T., Patron, M., MacVicar, T., Ahola, S., Wai, T., Barth, E., Rugarli, E.I., Bergami, M., Langer, T. (2019). Loss of the mitochondrial i‐AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol. Med. 11 pii: e9288.
Göbel, J., Pelzer, P., Engelhardt, E., Sakthivelu, V., Jahn, H.M., Milica, J., Folz-Donahue, K., Schauss, A., Ghanem, A., Conzelmann,, K.K., Frese, C., Motori, E., Bergami, M. (2019). Mitochondrial fusion in reactive astrocytes coordinates local metabolic domains to promote vascular repair. BioRxiv, doi: https://doi.org/10.1101/657999.
Göbel, J. Motori, E., and Bergami, M. (2018). Spatiotemporal control of mitochondrial network dynamics in astroglial cells. Biochem. Biophys. Res. Commun. 500, 17-25.
Jahn, H.M., Bergami, M. (2018). Critical periods regulating the circuit integration of adult-born hippocampal neurons. Cell Tissue Res. 371, 23-32.
Bergami, M., Masserdotti, G., Temprana, S., Motori, E., Eriksson, T.E., Göbel, J., Yang, S.M., Conzelmann, K.K., Schinder, A.F., Götz, M. and Berninger, B. (2015). A critical period for experience-dependent remodelling of adult-born neuron connectivity. Neuron 85, 710-717.