UNIVERSITÄT ZU KÖLN

Sabine Eming
Department of Dermatology, Medical Faculty,
University of Cologne

Phone: +49 221 / 478 3196  
E-mail: Sabine.Eminguni-koeln.de
For more information and contact please visit the EMING LAB.

Running time within the CRC 1218: 07/2020 - 06/2028.
 

Abstract

In the previous funding phase, we showed that mitochondrial metabolism coordinates the stage-specific activation and effector functions of macrophages to ensure effective wound healing in the skin. Based on our findings, we propose in the next funding period to further unravel the molecular signals that mediate the dynamics of mitochondrial metabolism and to decipher how metabolic rewiring is linked to macrophage function over the time course of wound healing. The long-term goal of this project is to understand how mitochondrial metabolism in macrophages regulates tissue repair and ultimately advance the development of therapeutic approaches to improve wound healing disorders in patients.

Project-related publications

Sanin DE*, Ge Y, Marinkovic E, Kabat AM, Castoldi A, Caputa G, Grzes KM, Curtis JD, Thompson EA, Willenborg S, Dichtl S, Reinhardt S, Dahl A, Pearce EL*, Eming SA*, Gerbaulet A*, Roers A*, Murray PJ*, Pearce EJ* (2022). A common framework of monocyte-derived macrophage activation. Sci Immunol 7(70):eabl7482. DOI: 10.1126/sciimmunol.abl7482. *shared corresponding authors

Eming SA*, Murray PJ*, Pearce EJ* (2021). Metabolic orchestration of the wound healing response. Cell Metab 33(9):1726-1743. DOI: 10.1016/j.cmet.2021.07.017. *shared corresponding authors

Willenborg, S., Sanin, D.E., Jais, A., Ding, X., Ulas, T., Nüchel, J., Popović, M., MacVicar, T., Langer, T., Schultze, J.L., Gerbaulet, A., Roers, A., Pearce, E.J., Brüning, J.C., Trifunovic, A., Eming, S.A. (2021). Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing.  Cell Metabolism (2021), https://doi.org/10.1016/j.cmet.2021.10.004

Schiffmann, L.M., Werthenbach, J.P., Heintges-Kleinhofer, F., Seeger, J.M., Fritsch, M., Günther, S.D., Willenborg, S., Brodesser, S., Lucas, C., Jüngst, C., Albert, M.C., Schorn, F., Witt, A., Moraes, C.T., Bruns, C., Pasparakis, M., Krönke, M., Eming, S.A., Coutelle, O., Kashkar, H. (2020). Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth. Nat. Commun. 11:3653

Kiesewetter, A., Cursiefen, C., Eming, S.A.*, and Hos, D.* (2019). Phase-specific functions of macrophages determine injury-mediated corneal hem- and lymphangiogenesis. Sci. Rep. 9, 308. (*corresponding authors)

Do, N.N.*, Willenborg, S.*, Eckes, B., Sengle, G., Zauke, F., and Eming, S.A. (2018). Myeloid cell-restricted STAT3 signaling controls a cell autonomous anti-fibrotic repair program. J. Immunol. 201, 663-674. (* shared first authorship)

Eming, S.A., Wynn, T.A., and Martin, P. (2017). Inflammation and metabolism in tissue repair and regeneration. Science 356, 1026-1030.

Knipper, J.A., Willenborg, S., Brinckmann, J., Bloch, W., Maaß, T., Wagener, R., Krieg, T., Sutherland, T., Migge, T., Richardson, R., Hammerschmidt, M., Allen, J.E., and Eming, S.A. (2015). IL-4Rα signaling in myeloid cells controls collagen fibril assembly in skin repair. Immunity 43, 803-816.

Ding, X., Lucas, T., Marcuzzi, G.P., Pfister, H., and Eming, S.A. (2015). Distinct functions of epidermis- and myeloid cell specific VEGF-A in human papillomavirus type 8-mediated tumorigenesis. Cancer Res. 75, 330-343.

Knuever, J., Willenborg, S., Ding, X., Akyüz, M.D., Partridge, L., Niessen, C.M., Brüning, J.C., and Eming, S.A. (2015). Myeloid cell-restricted Insulin/IGF-1 receptor deficiency protects against skin inflammation. J. Immunol. 195, 5296-5308.

Eming, S.A., Martin, P., and Tomic-Canic, M. (2014). Wound Repair and Regeneration: Mechanisms, signaling, and translation. Sci. Transl. Med. 6, 265sr6.

Willenborg, S., Lucas, T., van Loo, G., Knipper, J., Krieg, T., Haase, I., Brachvogel, B., Hammerschmidt, M., Nagy, A, Ferrara, N., Pasparakis, M., and Eming, S.A. (2012). CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood 120, 613-625.

Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., and Eming, S.A. (2010). Differential roles of macrophages in diverse phases of skin repair. J. Immunol. 184, 3964-3977.