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Schulte, U.; den Brave, F., Haupt, A., Gupta, A., Song, J., Müller, C.S., Engelke, J., Mishra, S., Mårtensson, C., Ellenrieder, L., Priesnitz, C., Straub, S.P., Doan, K.N., Kulawiak, B., Bildl, W., Rampelt, H., Wiedemann, N., Pfanner, N., Fakler, B. and Becker, T. Mitochondrial complexome reveals quality control pathways of protein import (2023). Nature. doi.org/10.1038/s41586-022-05641-w.

Takeda, H., Busto, J.V., Lindau, C., Tsutsumi, A., Tomii, K., Imai, K., Yamamori, Y., Hirokawa, T., Motono, C., Ganesan, I., Wenz, L.S., Becker, T., Kikkawa, M., Pfanner, N., Wiedemann, N. and Endo, T. (2023) A multipoint guidance mechanism for b-barrel folding on the SAM complex. Nat. Struct. Mol. Biol. doi.org/10.1038/s41594-022-00897-2.

Song, J., Steidle, L., Steymans, I., Singh, J., Sanner, A., Böttinger, L., Winter, D. and Becker, T. (2023). The mitochondrial Hsp70 controls the assembly of the F1FO-ATP synthase. Nat. Commun. 14, 39.



Hermeling, J. CW., Herholz, M., Baumann, L., Cores, E.C., Zečić, A., Hoppe, T., Riemer, J., Trifunovic, A. (2022). Mitochondria-originated redox signalling regulates KLF-1 to promote longevity in Caenorhabditis elegans. Redox Biology 2022,  https://doi.org/10.1016/j.redox.2022.102533


Jacobs, L.J., Hoehne, M.N., Riemer, J. (2022). Measuring Intracellular H2O2 in Intact Human Cells Using the Genetically Encoded Fluorescent Sensor HyPer7. Bio-protocol 12 (20).

Rödl, S., den Brave, F., Räschle, M., Kizmaz, B., Lenhard, S., Groh, C., Becker, H., Zimmermann, J., Morgan, B., Richling, E., Becker, T. and Herrmann, J.M. (2022). The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import. Life Sci. Alliance 6, e202201526.

Bolgi, O., Silva-Garcia, M., Ross, B., Pilla, E., Kari, V., Killisch, M., Spitzner, M., Stark, N., Lenz, C., Weiss, K., Donzelli, L., Gorrell, M.D., Grade, M., Riemer, J., Urlaub, H., Dobbelstein, M., Huber, R., Geiss-Friedlander, R. (2022). Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair. EMBO Rep. e54136.


Ravanelli, S., Li Q., Annibal A., Trifunovic A., Antebi A., Hoppe T. (2022). Reprograming of proteasomal degradation by branched chain amino acid metabolism.  Aging Cell 2022, https://doi.org/10.1111/acel.13725

Ahola, M., Rivera, M. P., Hermans, S., Chandragiri, S., Giavalisco, P., Nolte, H., Langer, T. (2022). OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy.  Cell Metab. 2022 Sep 8;S1550-4131(22)00360-6. doi: 10.1016/j.cmet.2022.08.017.


Jacobs, L.J., Riemer, J. (2022) Maintenance of small molecule redox homeostasis in mitochondria. FEBS Lett. doi: 10.1002/1873-3468.

Balaji V., Müller L., Lorenz R., Kevei E., Zhang W.H., Santiago U., Gebauer J., Llamas E., Vilchez D., Camacho C.J., Pokrzywa W., Hoppe T. (2022). A Dimer-Monomer Switch Controls CHIP-Dependent Substrate Ubiquitylation and Processing. Mol Cell. 2022, doi: https://doi.org/10.1016/j.molcel.2022.08.003

Patron, M., Tarasenko, D., Nolte, H., Ghosh, M.,  Ohba, Y., Lasarzewski, Y., Ahmadi, Z.A., Cabrera-Orefice, A., Eyiama, A., Kellermann, T., Rugarli, E.I., Brandt, U., Meinecke, M., Langer, T. (2022). Regulation of mitochondrial proteostasis by the proton gradient. The EMBO Journal (2022)e110476. https://doi.org/10.15252/embj.2021110476


Salscheider, S.L., Gerlich, S., Cabrera-Orefice, A., Peker, E., Rothemann, R.A., Murschall, L.M., Finger, Y., Szczepanowska, K., Ahmadi, Z.A., Guerrero-Castillo, S., Erdogan, A., Becker, M., Ali, M., Habich, M., Petrungaro, C., Burdina, N., Schwarz, G., Klußmann, M., Neundorf, I., Stroud, D.A., Ryan, M.T., Trifunovic, A., Brandt, U., Riemer, J. (2022). AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5. The EMBO Journal (2022)e110784. https://doi.org/10.15252/embj.2022110784


Schatton, D., Di Pietro, G., Szczepanowska, K., Veronese, M., Marx, M.-C., Braunöhler, K., Esther, B., Müller, S., Giavalisco, P., Langer, T., Trifunovic, A., Rugarli, I.E. (2022). CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression. Elife. 2022 May 13;11:e74552. DOI: 10.7554/eLife.74552

Hoffmann, J.J. and Becker, T. (2022) Crosstalk between mitochondrial protein import and lipids. Int. J. Mol. Sci. 23, 5275.


Priesnitz, C., Böttinger, L., Zufall, N., Gebert, M., Guiard, B., van der Laan, M. and Becker, T. (2022) Coupling to Pam16 differentially controls the dual role of Pam18 in protein import and respiratory chain formation. Cell Rep. 39, 1108619.

Song, J. and Becker T. (2022) Fidelity of organellar protein targeting. Curr. Opin. Cell Biol. 75:102071.


Rumyantseva, A., Popovic, M., Trifunovic, A. (2022). CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis. Brain (Oxford Academic) awab303, https://doi.org/10.1093/brain/awab303


Wani, G.A., Sprenger, H.-G., Ndoci, K., Chandragiri, S., Acton, R.J., Schatton, D., Kochan, S.M.V., Sakthivelu, V., Jevtic, M., Seeger, J.M., Müller, S., Giavalisco, P., Rugarli, E.I., Motori, E., Langer, T., Bergami, M. (2022). Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L. Cell Reports • DOI:https://doi.org/10.1016/j.celrep.2022.110370

Hoehne, M.N., Jacobs, L.J.H.C., Lapacz, K.J., Calabrese, G., Murschall, L.M., Marker, T., Kaul, H., Trifunovic, A., Morgan, B., Fricker, M., Belousov, V.V., Riemer J. (2022) Spatial and temporal control of mitochondrial H2O2 release in intact human cells. EMBO J, e109169


Li, X., Straub, J., Medeiros, T.C., Den Brave, F., Peker, E., Atanassov, I., Stillger, K., Michaelis, J.B., Burbridge, E., Adrain, C., Münch, C., Riemer, J., Becker, T., Pernas, L.F. (2022). Mitochondria shed their outer membrane in response to infection-induced stress. Science  • Vol 375, Issue 6577 • DOI: 10.1126/science.abi4343



Flores-Romero, H., Hohorst, L., John, M., Albert, M-C., King, L. E, Beckmann, L., Szabo, T., Hertlein, V., Luo, X., Villunger, A., Frenzel, L. P., Kashkar, H., Garcia-Saez, A. J. (2021). BCL-2-family protein tBID can act as a BAX-like effector of apoptosis. The EMBO Journal (2021)e108690. https://doi.org/10.15252/embj.2021108690

Willenborg, S., Sanin, D.E., Jais, A., Ding, X., Ulas, T., Nüchel, J., Popović, M., MacVicar, T., Langer, T., Schultze, J.L., Gerbaulet, A., Roers, A., Pearce, E.J., Brüning, J.C., Trifunovic, A., Eming, S.A. (2021). Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing.  Cell Metabolism (2021), https://doi.org/10.1016/j.cmet.2021.10.004

den Brave, F., Gupta, A., Becker, T. (2021) Protein Quality Control at the Mitochondrial Surface. Front. Cell Dev. Biol. DOI: https://doi.org/10.3389/fcell.2021.795685

Guerrero-Castillo, S., van Strien J., Brandt, U. and Arnold, S. (2021) Ablation of mitochondrial DNA results in widespread remodeling of the mitochondrial complexome. EMBO Journal, 40, e108648.

Hevler J.F., Chiozzi, R.Z., Cabrera-Orefice, A., Brandt U., Arnold, S, and Albert J. R. Heck, A.J.R. (2021) Molecular characterization of a complex of apoptosis-inducing factor 1 with cytochrome c oxidase of the mitochondrial respiratory chain. Proc. Natl. Acad. Sci. USA, 118, e2106950118.

den Brave, F., Engelke, J. and Becker, T. (2021) Quality control of protein import into mitochondria. Biochem. J. 478, 3125-3143.

Geueke A., Mantellato G., Kuester F., Schettina P., Nelles M., Seeger J.M., Kashkar H., Niemann C. (2021)
The anti-apoptotic Bcl-2 protein regulates hair follicle stem cell function
EMBO Rep (2021)e52301. https://doi.org/10.15252/embr.202052301

Peker E., Erdogan A.J., Volkov A.N., Riemer J. (2021) Erv1 and Cytochrome c Mediate Rapid Electron Transfer via A Collision-Type Interaction. J Mol Biol. 433(15):167045

Schlagowski A.M., Knöringer K., Morlot S., Sánchez Vicente A., Flohr T., Krämer L., Boos F., Khalid N., Ahmed S., Schramm J., Murschall L.M., Haberkant P., Stein F., Riemer J., Westermann B., Braun R.J., Winklhofer K.F., Charvin G., Herrmann J.M. (2021) Increased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol. EMBO J. e107913

Kaspar S., Oertlin C., Szczepanowska K., Kukat A., Senft K., Lucas C., Brodesser S., Hatzoglou M., Larsson O., Topisirovic I., Trifunovic A. (2021)
Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR
Science Advances  26 May 2021: Vol. 7, no. 22, eabf0971; DOI: 10.1126/sciadv.abf0971

Müller L., Kutzner C.E., Balaji V., Hoppe T. (2021). In vitro analysis of E3 ubiquitin ligase function. J Vis Exp. 171, doi: 10.3791/62393.

He L., Sehrawat T.S., Verma V.K, Navarro-Corcuera A., Sidhu G., Mauer A., Luo X., Katsumi T., Chen J., Shah S., Arab J.P., Cao S., Kashkar H., Gores G.J., Malhi H., Shah V.H. (2021)
XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent in vitro and in vivo Phenotypes Owing to a Potential Zonal Inhibitory Role of SMAC
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Aravamudhan, S., Türk, C., Bock, T., Keufgens, L., Nolte, H., Lang, F., Krishnan, R.K., König, T., Hammerschmidt, P., Schindler, N., Brodesser, S., Rozsivalova, D.H., Rugarli, E., Trifunovic, A., Brüning, J., Langer, T., Braun, T., Krüger, M. (2021). Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein.  2021 Feb 5;154:41-59. doi.org/10.1016/j.yjmcc.2021.01.010

Kelly, B., Carrizo, G.E., Edwards-Hicks, J., Sanin, D.E., Stanczak, M.A., Priesnitz, C., Flachsmann, L.J., Curtis, J.D., Mittler, G., Musa, Y., Becker, T., Buescher, J.M. and Pearce, E.L. (2021) Sulfur sequestration promotes multicellularity during nutrient limitation. Nature 591, 471-476.

Takeda, H., Tsutsumi, A., Nishizawa, T., Lindau C., Busto, J.V., Wenz, L.S., Ellenrieder, L., Imai, K., Straub, S.P., Mossmann, W., Qiu, J., Yamamori, Y., Tomii, K., Suzuki, J., Murata, T., Ogasawara, S., Nureki, O., Becker, T., Pfanner, N., Wiedemann, N., Kikkawa, M. and Endo, T. (2021) Mitochondrial sorting and assembly machinery operates by b-barrel switching. Nature 590, 163-169.

Song, J., Herrmann, J.M. and Becker, T. (2021) Quality control of the mitochondrial proteome. Nat. Rev. Mol. Cell Biol. 22, 54-70.

Mellis A.-T., Roeper J., Misko A.L., Kohl J., Schwarz G. (2021). Sulfite Alters the Mitochondrial Network in Molybdenum Cofactor Deficiency.  doi: 10.3389/fgene.2020.594828.

Mellis, A.-T., Misko, A.L., Arjune, S., Liang, Y., Erdélyi, K., Ditrói, T., Kaczmarek, A. T., Nagy, P., Schwarz, G. (2021).
The role of glutamate oxaloacetate transaminases in sulfite biosynthesis and H 2 S metabolism. Redox Biol. 2021 Jan;38:101800. doi: 10.1016/j.redox.2020.101800.

Gupta, A. and Becker, T. (2021) Mechanisms and pathways of mitochondrial outer membrane protein biogenesis. Biochim. Biophys. Acta 1862, 148323.


den Brave, F. and Becker, T. (2020) Supercomplex formation boosts respiration. EMBO Rep. e51830

Bonekamp, N.A., Peter, B., Hillen, H.S. Felser, A., Bergbrede, T., Choidas, A., Horn, M., Unger, A., Di Lucrezia, R., Atanassov,, I., Li, X., Koch, U., Menninger, S., Boros,, J., Habenberger, P., Giavalisco, P., Cramer, P., Denzel, M.S., Nussbaumer, P., Klebl, B., Falkenberg, M., Gustafsson, C.M., Larsson, N.G  (2020). Small-molecule inhibitors of human mitochondrial DNA transcription. Nature 588, 712–716. https://doi.org/10.1038/s41586-020-03048-z

Rumyantseva, A., Motori, E., Trufunovic, A. (2020). DARS2 is indispensable for Purkinje cell survival and protects against cerebellar ataxia". Hum Mol Genet.; 2020 Oct 10;29(17):2845-2854.     
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Kirschberg M, Heuser S, Marcuzzi GP, Hufbauer M, Seeger JM, Đukić A, Tomaić V, Majewski S, Wagner S, Wittekindt C, Würdemann N, Klussmann JP, Quaas A, Kashkar H, Akgül B. (2020)
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Bergami M., Motori E., (2020) Reweaving the Fabric of Mitochondrial Contact Sites in Astrocytes. DOI: 10.3389/fcell.2020.592651.

Albert, M.C., Brinkmann, K., Pokrzywa, W., Günther, S.D., Krönke, M., Hoppe, T. & Kashkar, H. (2020). CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damageCell Death Dis 11, 740

Joaquim M., Escobar-Henriques M. (2020). Role of Mitofusins and Mitophagy in Life or Death Decisions. DOI: 10.3389/fcell.2020.572182

Escobar-Henriques M., Vincent A. (2020) Mitochondrial Surveillance by Cdc48/p97: MAD vs. Membrane Fusion. DOI: 10.3390/ijms21186841

Motori, E., Atanassov, I., Kochan, S.M.V., Folz-Donahue, K., Sakthivelu, V., Giavalisco, P., Toni, N., Puyal, J., Larsson, N.-G. (2020). Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunctionScience Advances; Vol. 6, no. 35, eaba8271; DOI: 10.1126/sciadv.aba8271

Finger Y., Habich M., Gerlich S., Urbanczyk S., Logt E., Koch J., Schu L., Lapacz K.J., Ali M, Petrungaro C., Salscheider S.L., Pichlo C., Baumann U., Mielenz D., Brachvogel B., Hofmaann K., Riemer J. . (2020). Proteasomal degradation induced by DPP9‐mediated processing competes with mitochondrial protein import. EMBO Journal 2020 Aug e103889

Göbel, J., Engelhardt, E., Pelzer, P., Sakthivelu, V., Jahn, H.M., Jevtic, M., Folz-Donahue, K., Kukat, C., Schauss, A., Frese, C.K., Giavalisco, P., Ghanem, A., Conzelmann, K-K., Motori, E., Bergami, M. (2020). Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling. Cell Metab. 2020 Apr 7; 31(4): 791–808.e8.; https://doi.org/10.1016/j.cmet.2020.03.005

Schiffmann, L.M., Werthenbach, J. P., Heintges-Kleinhofer, F., Seeger, J.M., Fritsch, M., Günther, S. D. Willenborg, S., Brodesser, S., Lucas, C., Jüngst, C., Albert, M. C., Schorn, F., Witt, A., Moraes, C. T., Bruns, C. J., Pasparakis, M., Krönke, M., Eming, S. A., Coutelle, O., and Kashkar, H. (2020) . Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth. Nat. Commun. 11, 3653 (2020). https://doi.org/10.1038/s41467-020-17472-2. University of Cologne, Press release

Hofsetz, E., Demir, F., Szczepanowska, K., Kukat, A., Kizhakkedathu[1], J., Trifunovic, A., Huesgen, P.F. (2020). The Mouse Heart Mitochondria N Terminome Provides Insights Into ClpXP-mediated Proteolysis. Mol Cell Proteomics ;mcp.RA120.002082. DOI: 10.1074/mcp.RA120.002082. Online ahead of print.

Murschall L.M., Gerhards A., MacVicar T., Peker E., Hasberg L., Wawra S., Langer T., Riemer J. (2020). The C-terminal region of the oxidoreductase MIA40 stabilizes its cytosolic precursor during mitochondrial import.
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Hoppe T., Cohen E. (2020). Organismal Protein Homeostasis Mechanisms. DOI: 10.1534/genetics.120.301283

Timper, K., del Río-Martín, A., Cremer, A.L., Bremser, S., Alber, J. Giavalisco, P. Varela, L., Heilinger, C., Nolte, H., Trifunovic, A. Horvath, T.L., Kloppenburg, P., Backes, H., Brüning, J.C.  (2020). GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function. Cell Metab. S1550-4131(20)30240-0. doi: 10.1016/j.cmet.2020.05.001. Online ahead of print.

Ravanelli, S., den Brave, F., Hoppe, T. (2020). Mitochondrial Quality Control Governed by Ubiquitin. Front. Cell Dev. Biol. | doi: 10.3389/fcell.2020.00270

Szczepanowska, K., Senft, K., Heidler, J., Herholz, M., Kukat, M.A., Höhne, N., Hofsetz, E., Becker, C.,  Kaspar, S., Giese, H., Zwicker, K., Guerrero-Castillo, S, Baumann, L., Kauppila, J., Rumyantseva, A., Müller, S., Frese, C.K., Brandt, U., Riemer, J., Wittig, I., and Trifunovic, A. (2020) A salvage pathway maintains highly functional respiratory complex I. Nature Communications 11, 1643.

Pla-Martin, D.,  Schatton, D., Wiederstein, J.L., Marx, M.C.,  Khiati, S., Krüger, M., Rugarli, E.I. (2020). CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy. EMBO J. e102731. doi.org/10.15252/embj.2019102731. [Epub ahead of print]

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Murru, S., Hess, S., Barth, E., Almajan, E.R., Schatton, D., Hermans, S., Brodesser, S., Langer, T., Kloppenburg, P., Rugarli, E.I. (2019). Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration. GLIA 67, 1526-1541.

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Schuster, R., Anton, V., Simoes, T., Altin, S., den Brave, F., Hermanns, T., Hospenthal, M., Komander, D., Dittmar, G., Dohmen, R.J., Escobar-Henriques, M. (2019). Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation. Life Sci. Alliance, 3(1). pii: e201900476. doi: 10.26508/lsa.201900476. Print 2020 Jan.

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Silva Ramos, E., Motori, E., Brüser, C., Kühl, I., Yeroslaviz, A., Ruzzenente, B., Kauppila, J.H.K., Busch, J.D., Hultenby, K., Habermann, B.H., Jakobs, S., Larsson, N.G., and Mourier, A. (2019). Mitochondrial fusion is required for regulation of mitochondrial DNA replication. PLoS Genet. 15, e1008085.

Rangaraju, V.*, Lewis, T.*, Hirabayashi, Y.*, Bergami, M.*, Motori, E.*, Cartoni, R.*, Kwon, S.K., and Courchet, J. (2019). Pleiotropic Mitochondria: The influence of mitochondria on neuronal development and disease. J. Neurosci. 39, 8002-8208. *equal contribution

Ren, S.Q., Li, Z., Lin, S., Bergami, M., and Shi, S.H. (2019). Precise long-range microcircuit-to-microcircuit communication connects the frontal and sensory cortices in the mammalian brain. Neuron. 104, 385-401.e3.

Sprenger, H.G., Wani, G., Hesseling, A., König, T., Patron, M., MacVicar, T., Ahola, S., Wai, T., Barth, E., Rugarli, E.I., Bergami, M., Langer, T. (2019). Loss of the mitochondrial i‐AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol. Med. 11 pii: e9288.

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