B12 | Cardiolipin-dependent regulation of T cell immunity
Mauro Corrado
CECAD Research Center
E-mail: mcorrado
uni-koeln.de
Phone: +49 - 221 / 478 84167
For more information and contact please visit the CORRADO LAB.
Running time within the CRC 1218: 03/2022 - 06/2028.
Abstract
Mitochondrial plasticity is critical to modulate T cell function in response to antigen-driven and environmental signals. This allows an effective immune surveillance and maintenance of tissue homeostasis while avoiding autoimmunity and inflammation. Cardiolipin is the characterizing and most abundant lipid species of the inner mitochondrial membrane (IMM). A mouse model of cardiolipin (CL) synthesis deficiency in T cells presents with immunodeficiency upon infection and a multi-organ highly inflammatory state. How this is achieved is not clear. Therefore, in this project we will investigate the mechanisms and physiological consequences of CL-deficiency in T cells.
Project-related publications
Guhathakurta S, Erdogdu NU, Hoffmann JJ, Grzadzielewska I, Schendzielorz A, Seyfferth J, Mårtensson CU, Corrado M, Karoutas A, Warscheid B, Pfanner N, Becker T, Akhtar A (2023). COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function. Nat Metab. DOI: 10.1038/s42255-023-00904-w.
Villa M, Sanin DE, Apostolova P, Corrado M, Kabat AM, Cristinzio C, Regina A, Carrizo GE, Rana N, Stanczak MA, Baixauli F, Grzes KM, Cupovic J, Solagna F, Hackl A, Globig AM, Hassler F, Puleston DJ, Kelly B, Cabezas-Wallscheid N, Hasselblatt P, Bengsch B, Zeiser R, Sagar, Buescher JM, Pearce EJ, Pearce EL (2023). Prostaglandin E (2) controls the metabolic adaptation of T cells to the intestinal microenvironment. bioRxiv DOI: 10.1101/2023.03.13.532431.
Baixauli F, Piletic K, Puleston DJ, Villa M, Field CS, Flachsmann LJ, Quintana A, Rana N, Edwards-Hicks J, Matsushita M, Stanczak MA, Grzes KM, Kabat AM, Fabri M, Caputa G, Kelly B, Corrado M, Musa Y, Duda KJ, Mittler G, O'Sullivan D, Sesaki H, Jenuwein T, Buescher JM, Pearce EJ, Sanin DE, Pearce EL (2022). An LKB1-mitochondria axis controls T(H)17 effector function. Nature 610:555-561. DOI: 10.1038/s41586-022-05264-1.
Corrado M, Pearce EL (2022). Targeting memory T cell metabolism to improve immunity. J Clin Invest 132. DOI: 10.1172/JCI148546.
Corrado, M., Edwards-Hicks, J., Villa, M., Flachsmann, L.J., Sanin, D.E., Jacobs, M., Baixauli, F., Stanczak, M., Anderson, E., Azuma, M., Quintana, A., Curtis, J.D., Clapes, T., Grzes, K.M., Kabat, A.M., Kyle, R., Patterson, A.E., Geltink, R.K., Amulic, B., Steward, C.G., Strathdee, D., Trompouki, E., O'Sullivan, D., Pearce, E.J. , Pearce, E.L. (2020). Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity. Cell. Metab. 32(6):981-995.e7. DOI: 10.1016/j.cmet.2020.11.003.