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Z04 - Bioenergetics

Aleksandra Trifunovic
CECAD Forschungszentrum/Institut für Mitochondriale Erkrankungen und Alterung
Universitätsklinikum Köln
E-mail: aleksandra.trifunovicSpamProtectionuk-koeln.de
Phone: +49 - 221 / 478 84291
For more information and contact please visit the TRIFUNOVIC LAB; see also project B01.

Hamid Kashkar
CECAD Research Center/Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), University Hospital Cologne

E-mail: H.KashkarSpamProtectionuni-koeln.de
Phone: +49 - 221 / 478 84091
For more information and contact please visit the KASHKAR LAB; see also project B05.

Running time within the CRC 1218: 07/2016 - 06/2020.
The Z04 project was merged with the project Z02, Proteomics and the Metabolomics/Lipidomics facility to form the central project Bioanalytical platform Z02



Mitochondrial bioenergetics is of central importance in diverse cellular actions involved in cellular homeostasis and stress responses. However, the complexity and dynamics of mitochondrial energy metabolism represent a great challenge for the integrative understanding of how mitochondria interfere with cellular functions. Therefore, the Z04 project intends to build up a much-needed Bioenergetic facility that should fulfill the need for in-depth analysis of metabolic processes in cells.

Project-related publications

Herholz, M., Cepeda, E., Baumann, L., Kukat, A., Hermeling, J., Maciej, S., Szczepanowska, K., Pavlenko, V., Frommolt, P., and Trifunovic, A. (2019). KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants. Nat. Commun. 10, 3323. 

Becker, C., Kukat, A., Szczepanowska, K., Hermans, S., Senft, K., Brandscheid, C.P., Maiti, P., and Trifunovic, A. (2018). CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. EMBO Rep. 19:e45126. [Epub ahead of print].

Seiferling, D., Szczepanowska, K., Becker, C., Senft, K., Hermans, S., Maiti, P., König, T., Kukat, A., Trifunovic, A. (2016). Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep. 17, 953-964.

Coutelle, O., Hornig-Do, H.T., Witt, A., Andree, M., Schiffmann, L.M., Liwschitz, M., Seeger, J.M., Piekarek, M., Brinkmann, K., Hallek, M., Krönke, M., Trifunovic, A., Eming, S.A., Wiesner, R.J., Hacker, U.T., and Kashkar, H. (2014). Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing. EMBO Mol. Med. 6, 624-639.