B09 | Mitochondrial defense against an intracellular parasite
Running time within the CRC 1218: 07/2020 - 06/2024.
Mitochondria regulate a myriad of cellular functions, but in the context of infection these dynamic organelles are considered exploitable targets for microbes. However, the fact that pathogens have developed strategies to perturb mitochondrial function supports the existence of mitochondrial counterstrategies to defend against pathogens. Our overarching goal is to deepen our understanding of how mitochondria regulate cellular defense against microbes. In this project, we will explore two novel mechanisms of mitochondrial defense during infection with human parasite Toxoplasma.
Pernas, L. (2019). Finding a Direction-How do Mitochondria Know Where to Go? MSphere. 4, e0032119
Pernas, L., Boothroyd, J.C., and Scorrano, L. (2018). Mitochondria restrict Toxoplasma growth by limiting its fatty acids uptake. Cell Metab. 27, 886-897 e884.
Blank, M.L., Parker, M.L., Ramaswamy, R., Powell, C.J., English, E.D., Adomako-Ankomay, Y., Pernas, L., Workman, S.D., Boothroyd, J.C., Boulanger, M.J., and Boyle, J.P. (2018). A Toxoplasma gondii locus required for the direct manipulation of host mitochondria has maintained multiple ancestral functions. Mol. Microbiol. 108, 519-535.